Probiotics with anxiety and tension
We recently added the Lactiplantibacillus plantarum P-8 to our portfolio. A well-conducted RCT shows that this strain is effective against anxiety and tension (1). The same study also found evidence for an effect against stress, albeit slightly less strong (1). That this probiotic has a beneficial effect on anxiety and tension fits with the growing body of research showing that the microbiome plays a role in anxiety, tension, and depression (2) and that probiotics can improve this (3). It is suspected that this effect has to do with, among other things, the influence of the microbiome and probiotics on inflammatory activity (2.4). Anti-inflammatory effects have also been seen in L. plantarum P-8 in studies with the single strain or in combination with other strains (1,5,6). There is also evidence in animal models that this strain has an effect on oxidative stress (7.8), an aspect that is also associated with anxiety, tension and depression (9,10). Finally, it is interesting that research with L. plantarum P-8 shows that this strain can increase secretory IgA (11,12), as it is known that stress can lead to decreased sIgA excretion (13). It can be concluded that the microbiome influences multiple mechanisms involved in anxiety and tension and that probiotics can modulate this.
Further evidence and information about this strain can be found in the description of this ingredient in our system.
References:
- https://doi.org/10.1016/j.clnu.2018.09.010
- https://doi.org/10.1016/j.cpr.2020.101943
- https://doi.org/10.1016/j.neubiorev.2019.03.023
- https://doi.org/10.1002/jnr.24476
- https://doi.org/10.1007/s00394-020-02437-4
- https://doi.org/10.1111/1751-7915.13661
- https://doi.org/10.1007/s00394-020-02437-4
- https://doi.org/10.3390/ani10040548
- https://doi.org/10.1080/10715762.2018.1475733
- https://doi.org/10.4161/oxim.2.2.7944
- https://doi.org/10.1016/j.nut.2013.11.018
- https://doi.org/10.1016/j.intimp.2015.07.024
- https://doi.org/10.3389/fnint.2013.00086