New strain: L. sakei probio65
Recently we were able to add a unique strain to the range from which you can choose, the Latilactobacillus sakei probio65. This bacterium has been isolated from kimchi and has excellent gastrointestinal survival (1). Much research has been devoted to the effect of L. sakei probio65 on atopic eczema. This includes in vitro and preclinical studies (see e.g. 1-3), but also two well-conducted RCTs (4,5). The latter show quite strong effects on various aspects of atopic eczema. Furthermore, in vitro research shows a fairly strong inhibitory effect on various pathogens (1). Interestingly, this strain can also inhibit -glucosidase and α-amylase activity (6,7). These are enzymes that break down carbohydrates and inhibition of these enzymes is seen as a way to treat diabetes and is the mechanism of action of the diabetes drug acarbose (6). Indeed, an animal model showed an improvement in blood sugar after administration of L. sakei probio65 (6), indicating that this strain may also be useful in metabolic syndrome and diabetes. Other evidence and information about this building block can be found in the description of this ingredient in our system.
On June 28, we will explain the effects in atopic eczema in more detail in our webinar about allergy.
New prebiotic: PHGG
Many fibers and prebiotics have been studied in fairly high doses. Thirty grams a day is not uncommon. In addition, literature and practice show that the most well-known prebiotics, FOS and GOS, regularly cause unwanted side effects such as bloating or abdominal pain. One of the exceptions to this is partially hydrolyzed guar gum (PHGG). In addition to the usual higher daily doses, PHGG has also been studied in a dose of approximately 5 grams per day. Guar gum is extracted from the guar bean and is inherently extremely viscous, which is why it is partially hydrolyzed enzymatically (8). Particularly in the 1980s and 1990s, a great deal of research has been done into the effect on glucose response and insulin resistance (with different doses), which consistently shows a beneficial effect (see e.g. 9 and 10). This makes PHGG a good choice as an ingredient in patients with metabolic syndrome, (pre)diabetes, or other indications of insulin resistance. In addition, a lot of research has been done that has shown a beneficial effect on abdominal complaints such as diarrhea, constipation, abdominal pain, and IBS (see eg 8,11,12). A well-conducted study also shows a beneficial effect for SIBO (13), which makes PHGG a good addition to SIBO treatment. Other evidence and information about this building block can be found in the description of this ingredient in our system.
References:
- https://doi.org/10.1089/jmf.2007.0144
- https://doi.org/10.1111/jam.12229
- https://doi.org/10.5021/ad.2014.26.2.150
- https://doi.org/10.1016/j.anai.2010.01.020
- https://doi.org/10.1007/s12602-020-09654-7
- https://doi.org/10.3390/biology10040348
- https://doi.org/10.1111/jfbc.12230
- https://doi.org/10.1007/s10620-005-2713-7
- https://doi.org/10.1111/j.1464-5491.1987.tb00843.x
- https://doi.org/10.5144/0256-4947.1990.525
- https://doi.org/10.3390/nu11092170
- https://doi.org/10.4318/tjg.2010.0121
- https://doi.org/10.1111/j.1365-2036.2010.04436.x