ew strain: Lacticaseibacillus rhamnosus SP1
When we encounter interesting ingredients for microbiome treatments, we try to make these available for you so that the possibilities to treat patients continue to expand. We have now added the strain Lacticaseibacillus rhamnosus SP1 which has been studied, among others, for its effect on acne and on caries. Importantly, many effects are strain-specific and there are many strains of the L. rhamnosus species. It must be noted that not all strains of this species can be expected to have the same effect as this strain named SP1.
A small but well-conducted RCT with L. rhamnosus SP1 shows that it leads to improved or markedly improved acne symptoms compared to placebo (1). In addition, this study showed that the use of L. rhamnosus SP1 induced a clear reduction of expression of insulin-like growth factor 1 (IGF1) in skin samples of the probiotic group compared to placebo, which is evidence for an effect on insulin signaling. Indeed, accumulating evidence shows that disturbed gut microbiota is associated with acne, partly due to its effect on insulin signaling, but clinical trials with probiotic interventions are scarce (2). This in itself makes L. rhamnosus SP1 an interesting addition.
Another study conducted with this strain is a large RCT (and a subgroup analysis thereof) that investigated the effect of this strain on the prevention of caries in preschool children. The results shows that, compared to placebo, L. rhamnosus SP1 effectively prevents caries (3,4). Another RCT on oral health provides evidence for an effect on Candida-associated denture stomatitis (5). This study also provides direct evidence for an inhibiting effect on (oral) candida.
More information on this strain and its effects can be found under the (i)-button on our platform.
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