{"id":227453,"date":"2026-08-06T16:43:22","date_gmt":"2026-08-06T14:43:22","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227453"},"modified":"2026-08-06T16:54:14","modified_gmt":"2026-08-06T14:54:14","slug":"new-ingredient-for-patients-with-fatigue-and-impaired-resilience","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/new-ingredient-for-patients-with-fatigue-and-impaired-resilience\/","title":{"rendered":"48: New ingredient for patients with fatigue and impaired resilience"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Synbio\u00ae \u2013 a two-strain probiotic for fatigue, digestive comfort, and more<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>We recently added a new building block, Synbio\u00ae, consisting of two probiotic strains, <em>L. rhamnosus<\/em>&nbsp;IMC501 and&nbsp;<em>L. paracasei<\/em>&nbsp;IMC502.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Fatigue reduction<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>One of the most intriguing indications for this two-strain probiotic is prevention of fatigue. In a pilot RCT with airline flight crew \u2013 a group under considerable physical and circadian stress \u2013 participants receiving Synbio\u00ae showed a larger reduction in fatigue than the placebo group. A larger RCT in athletes found a similar pattern: greater reduction in tiredness frequency in the probiotic group versus placebo (2). These two studies looked at different types of fatigue \u2013 clinical and exercise-induced \u2013 yet both point in the same direction, suggesting a broader effect on fatigue regardless of cause. Interestingly, both trials also reported fewer common colds in the probiotic group (1,2), hinting that these strains may help support the body under physically demanding conditions.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Digestive comfort, histamine reduction, and other indications<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>In addition, this set of probiotic strains is also well-supported by evidence for digestive comfort. A meta-analysis of clinical trials found substantial effect on constipation and on maintaining intestinal regularity (3), while several additional clinical studies report reductions in bloating (2,4,5). Moreover, a clinical study in elderly showed that supplementation led to lower histamine levels (6). Other areas with supporting evidence include e.g. inhibiting pathogens (including common skin pathogens such as <em>Staphylococcus aureus<\/em> and <em>Pseudomonas aeruginosa<\/em> (7,8)) among others. For full details, see the i-button of this ingredient on our platform.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do you want to read more insights?<\/strong><br>You can follow us on LinkedIn:\u00a0<a href=\"https:\/\/www.linkedin.com\/company\/microbiome-center\/\">https:\/\/www.linkedin.com\/company\/microbiome-center\/<\/a><br>Or read previous insights flashes at:\u00a0<a href=\"https:\/\/microbiome-center.nl\/en\/practitioners\/kennisflits\/\">https:\/\/microbiome-center.nl\/en\/practitioners\/kennisflits\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3390\/microorganisms11040924\">https:\/\/doi.org\/10.3390\/microorganisms11040924<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.calameo.com\/read\/000151313a1e85c9465fb\">https:\/\/www.calameo.com\/read\/000151313a1e85c9465fb<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/fermentation10100518\">https:\/\/doi.org\/10.3390\/fermentation10100518<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3109\/09637486.2014.940284\">https:\/\/doi.org\/10.3109\/09637486.2014.940284<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.proquest.com\/openview\/95ea9bc72df6f50778d280008dee3852\/\">https:\/\/www.proquest.com\/openview\/95ea9bc72df6f50778d280008dee3852\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/microorganisms11030801\">https:\/\/doi.org\/10.3390\/microorganisms11030801<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/jam.14482\">https:\/\/doi.org\/10.1111\/jam.14482<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00394-009-0021-2\">https:\/\/doi.org\/10.1007\/s00394-009-0021-2<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Synbio\u00ae \u2013 a two-strain probiotic for fatigue, digestive comfort, and more We recently added a new building block, Synbio\u00ae, consisting of two probiotic strains, L. rhamnosus&nbsp;IMC501 and&nbsp;L. paracasei&nbsp;IMC502. Fatigue reduction One of the most intriguing indications for this two-strain probiotic is prevention of fatigue. In a pilot RCT with airline flight crew \u2013 a group [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[],"class_list":["post-227453","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>48: New ingredient for patients with fatigue and impaired resilience - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"48: New ingredient for patients with fatigue and impaired resilience - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Synbio\u00ae \u2013 a two-strain probiotic for fatigue, digestive comfort, and more We recently added a new building block, Synbio\u00ae, consisting of two probiotic strains, L. rhamnosus&nbsp;IMC501 and&nbsp;L. paracasei&nbsp;IMC502. 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