{"id":227451,"date":"2026-08-06T16:41:12","date_gmt":"2026-08-06T14:41:12","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227451"},"modified":"2026-08-06T16:41:19","modified_gmt":"2026-08-06T14:41:19","slug":"47-bringing-metabolome-insights-into-everyday-practice","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/47-bringing-metabolome-insights-into-everyday-practice\/","title":{"rendered":"47: Bringing metabolome insights into everyday practice"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>The metabolome: Adding a new layer of precision to treatment selection<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Last year, our partner Biovis introduced metabolome analysis. It measures metabolites that are produced by microbes in the gut, which means that it moves the analysis from \u201cwho is there?\u201d to \u201cwhat are they doing?\u201d. This adds a layer of precision that can aid the personalized treatment of patients, because it can show more than is visible when looking at the abundance of microbes only. As an example, it can happen that in the microbiome analysis not a single pathogen is present in high abundance and proteobacteria are also low, while the metabolome analysis shows high levels of toxic metabolites. In such case, this gives a clue that otherwise would have been missed about over-active pathogens that are important treatment targets.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You may have seen the \u201cmetabolome\u201d section in the traditional Biovis microbiome analysis. However, this did not measure the actual metabolites, but rather the abundance of bacteria that are capable of producing certain metabolites (e.g. TMA\/TMAO or equol). The new metabolome analysis, however, measures metabolites themselves.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The metabolome analysis is available separately, or as so-called Microbolome analysis, which combines the microbiome and metabolome measurements.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Easy translation of metabolome results into treatment decisions<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Biovis metabolome analysis has already provided valuable insights for some time, and Microbiome Center has now simplified the translation of these results into targeted treatment advice. We have implemented the metabolome analysis results in our advice aid and this (1) enables automatic scoring when you import the Biovis data, and (2) integrates the metabolome results in the personalized treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To link the metabolome results to ingredients, we have used the approach that we have developed and used for years, and which we recently&nbsp;<a href=\"https:\/\/doi.org\/10.1163\/18762891-bja00110\">published<\/a>&nbsp;in Beneficial Microbes. That is, we assess all available evidence for all ingredients, and we have now expanded the effects that we scan the literature for to effects on metabolites. For example, scientific research shows that our&nbsp;<em>Bifidobacterium adolescentis<\/em>&nbsp;SH001&nbsp;<a href=\"https:\/\/doi.org\/10.1128\/MRA.00541-23\">has the genes to produce GABA<\/a>&nbsp;and this strain has been shown in vitro to&nbsp;<a href=\"https:\/\/doi.org\/10.1128\/msphere.00673-25\">excel in GABA production<\/a>. As a second example, our&nbsp;<em>E. coli&nbsp;<\/em>MC231 can produce&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s44319-025-00386-9\">indole and various indole derivates<\/a>, but also&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/srep17324\">stimulate serotonin production<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Just like we did for complaints, medical background, and fecal analysis results, we have implemented all these effects on metabolites for each ingredient in our advice aid, and the algorithm takes this into account when generating a proposed personalized treatment. This means that the metabolome data is automatically taken into account, and therewith it has become very easy for you as practitioner to use the metabolome data in a targeted treatment of the patient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do you want to read more insights?<\/strong><br>You can follow us on LinkedIn:&nbsp;<a href=\"https:\/\/www.linkedin.com\/company\/microbiome-center\/\">https:\/\/www.linkedin.com\/company\/microbiome-center\/<\/a><br>Or read previous insights flashes at:&nbsp;<a href=\"https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/\">https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/<\/a><\/p>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The metabolome: Adding a new layer of precision to treatment selection Last year, our partner Biovis introduced metabolome analysis. It measures metabolites that are produced by microbes in the gut, which means that it moves the analysis from \u201cwho is there?\u201d to \u201cwhat are they doing?\u201d. This adds a layer of precision that can aid [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[],"class_list":["post-227451","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>47: Bringing metabolome insights into everyday practice - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"47: Bringing metabolome insights into everyday practice - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"The metabolome: Adding a new layer of precision to treatment selection Last year, our partner Biovis introduced metabolome analysis. 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