{"id":227443,"date":"2026-08-06T16:35:53","date_gmt":"2026-08-06T14:35:53","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227443"},"modified":"2026-08-06T16:36:00","modified_gmt":"2026-08-06T14:36:00","slug":"44-celiac-disease-and-gut-microbiome","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/44-celiac-disease-and-gut-microbiome\/","title":{"rendered":"44: Celiac disease and gut microbiome"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Celiac disease is not just genetic<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Celiac disease is often considered to have a genetic cause. It is a chronic systemic autoimmune disease that is characterized by loss of tolerance to dietary gluten. Although it occurs in genetically predisposed individuals, not every predisposed person develops the disease and there is substantial variability in both age of onset and symptom severity (1). The only available treatment is a gluten-free diet (GFD), but 30-40% of patients on a GFD continue to experience symptoms (1). A large body of evidence shows that the gut microbiome plays a significant role in the development of celiac disease (1,2). For example, it is known that gut dysbiosis precedes the onset of the disease, whereas genetically predisposed individuals who do not have dysbiosis remain healthy (3,4). Moreover, it is known that GFD has a beneficial effect on the microbiome composition and function but does not fully restore it (5). It can be argued that the beneficial effect of GFD is at least in part due to its effect on the gut microbiome and is not just due to the absence of immune-triggering gluten proteins. In line with this, scientific studies conclude that it is worthwhile considering treatment of the gut microbiome in patients with celiac disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>New probiotic strain alleviates celiac disease and gluten sensitivity symptoms<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unfortunately, not many probiotics have been studied for their effect on celiac disease, with only a few exceptions. The currently best studied probiotic in celiac disease is&nbsp;<em>Bifidobacterium longum<\/em>&nbsp;ES1 (CETCT 7374). About a dozen&nbsp;<em>in vitro<\/em>&nbsp;and animal studies have shown his strain\u2019s capability to degrade gliadin and to modulate immune responses to gluten (see e.g. 6-8). In addition, a small RCT in children with newly diagnosed celiac disease comparing GFD with GFD +&nbsp;<em>B. longum<\/em>&nbsp;ES1 showed that in the probiotic group important improvements were found in specific immune cells involved in the disease symptoms (9). In addition, pro-inflammatory cytokines were substantially lower in the group receiving the&nbsp;<em>B. longum<\/em>&nbsp;ES1 (9). Moreover, an open-label study in patients with non-celiac gluten sensitivity showed that compared to GFD only, the group on GFD +&nbsp;<em>B. longum<\/em>&nbsp;ES1 had more improvements in gastrointestinal symptoms (10). This strain is now available on the Microbiome Center platform. Although it will not be able to replace GFD, it can support patients with celiac disease or gluten sensitivity in further alleviating symptoms. This interesting probiotic strain also has good quality evidence for an effect on IBS, including diarrhea and abdominal pain (11,12), as well as on various other indications. For more information, see the detailed description behind the i-button on the Microbiome Center platform.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do you want to read more insights?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You can follow us on LinkedIn:&nbsp;<a href=\"https:\/\/www.linkedin.com\/company\/microbiome-center\/\">https:\/\/www.linkedin.com\/company\/microbiome-center\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Or read previous insights flashes at:&nbsp;<a href=\"https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/\">https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3389\/fmedt.2024.1413637\">https:\/\/doi.org\/10.3389\/fmedt.2024.1413637<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00430-017-0496-z\">https:\/\/doi.org\/10.1007\/s00430-017-0496-z<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1073\/pnas.2020322118\">https:\/\/doi.org\/10.1073\/pnas.2020322118<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1128\/spectrum.01468-24\">https:\/\/doi.org\/10.1128\/spectrum.01468-24<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu14102083\">https:\/\/doi.org\/10.3390\/nu14102083<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1021\/jf201212m\">https:\/\/doi.org\/10.1021\/jf201212m<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2010.06.015\">https:\/\/doi.org\/10.1016\/j.ijbiomac.2010.06.015<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1189\/jlb.1111581\">https:\/\/doi.org\/10.1189\/jlb.1111581<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1017\/S0007114514000609\">https:\/\/doi.org\/10.1017\/S0007114514000609<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.23736\/S1121-421X.20.02673-2\">https:\/\/doi.org\/10.23736\/S1121-421X.20.02673-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1080\/19490976.2024.2338322\">https:\/\/doi.org\/10.1080\/19490976.2024.2338322<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/jcm9082353\">https:\/\/doi.org\/10.3390\/jcm9082353<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Celiac disease is not just genetic Celiac disease is often considered to have a genetic cause. It is a chronic systemic autoimmune disease that is characterized by loss of tolerance to dietary gluten. Although it occurs in genetically predisposed individuals, not every predisposed person develops the disease and there is substantial variability in both age [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[],"class_list":["post-227443","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>44: Celiac disease and gut microbiome - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"44: Celiac disease and gut microbiome - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Celiac disease is not just genetic Celiac disease is often considered to have a genetic cause. It is a chronic systemic autoimmune disease that is characterized by loss of tolerance to dietary gluten. 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