{"id":227439,"date":"2026-08-06T16:33:20","date_gmt":"2026-08-06T14:33:20","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227439"},"modified":"2026-08-17T13:57:58","modified_gmt":"2026-08-17T11:57:58","slug":"42-our-first-own-strain-usable-for-ulcerative-colitis-prostatitis-diverticulitis-and-various-other-conditions","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/42-our-first-own-strain-usable-for-ulcerative-colitis-prostatitis-diverticulitis-and-various-other-conditions\/","title":{"rendered":"42: Our First Own Strain, Usable for Ulcerative Colitis, Prostatitis, Diverticulitis, and Various Other Conditions"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Launch of Microbiome Center\u2019s First Own Strain:&nbsp;<em>E. coli<\/em>&nbsp;MC231<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Two weeks ago, we celebrated the launch of our very first proprietary strain with a small festive ceremony. This strain,&nbsp;<em>Escherichia coli<\/em>&nbsp;MC231, was selected from a large set of potential strains and has undergone a development process of one and a half years, including genome sequencing, characterization, development of the production process, and stability testing.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/dev.studioboszkers.nl\/microbiome-center\/wp-content\/uploads\/2025\/03\/Kennisflits-0042-image.docx-400x300.jpg.webp\" alt=\"\" class=\"wp-image-12131\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Microbiome Center\u2019s Core Team Celebrates the Launch of E. coli MC231<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The&nbsp;<em>E. coli<\/em>&nbsp;MC231 strain was selected for two main reasons: First, the bacterial species&nbsp;<em>Escherichia coli<\/em>&nbsp;plays a crucial role in the human gut microbiome. Second, this specific strain is genetically almost identical to the well-researched&nbsp;<em>E. coli<\/em>&nbsp;Nissle 1917 (also known as Mutaflor\u00a9). This means that the scientific evidence supporting&nbsp;<em>E. coli<\/em>&nbsp;Nissle 1917 also applies to&nbsp;<em>E. coli<\/em>&nbsp;MC231. However, unlike Nissle, our MC231 strain remains stable at room temperature.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This strain has been extensively studied for ulcerative colitis and has shown, in meta-analyses of randomized controlled trials (RCTs), to be significantly more effective than a placebo and to have a comparable effect to the standard medication 5-ASA (see, for example, 1). These studies also demonstrate a clear anti-inflammatory effect (1). A small study even provides some evidence that this strain may be effective for Crohn\u2019s disease (2), which is rarely found with probiotics. Additionally, there is strong evidence of a beneficial effect on various gut disorders, including diverticulitis (3).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interestingly, this strain has also proven effective for certain conditions outside the gut. One example is a significant relapse-preventing effect in chronic bacterial prostatitis (4). Another example comes from an RCT with participants suffering from acne, rosacea, or seborrheic eczema, who showed clear improvement compared to the placebo group (5).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The&nbsp;<em>E. coli<\/em>&nbsp;MC231 strain is now available and has been included in the Advice Aid. More information on the scientific evidence can be found via the \u201ci\u201d icon next to the strain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.15403\/jgld.2014.1121.244.ecn\">https:\/\/doi.org\/10.15403\/jgld.2014.1121.244.ecn<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1097\/00004836-199712000-00021\">https:\/\/doi.org\/10.1097\/00004836-199712000-00021<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1097\/01.meg.0000049998.68425.e2\">https:\/\/doi.org\/10.1097\/01.meg.0000049998.68425.e2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00345-021-03773-8\">https:\/\/doi.org\/10.1007\/s00345-021-03773-8<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3748\/wjg.v22.i23.5415\">https:\/\/doi.org\/10.3748\/wjg.v22.i23.5415<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Launch of Microbiome Center\u2019s First Own Strain:&nbsp;E. coli&nbsp;MC231 Two weeks ago, we celebrated the launch of our very first proprietary strain with a small festive ceremony. This strain,&nbsp;Escherichia coli&nbsp;MC231, was selected from a large set of potential strains and has undergone a development process of one and a half years, including genome sequencing, characterization, development [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227439","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>42: Our First Own Strain, Usable for Ulcerative Colitis, Prostatitis, Diverticulitis, and Various Other Conditions - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"42: Our First Own Strain, Usable for Ulcerative Colitis, Prostatitis, Diverticulitis, and Various Other Conditions - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Launch of Microbiome Center\u2019s First Own Strain:&nbsp;E. coli&nbsp;MC231 Two weeks ago, we celebrated the launch of our very first proprietary strain with a small festive ceremony. 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