{"id":227437,"date":"2026-08-06T16:31:43","date_gmt":"2026-08-06T14:31:43","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227437"},"modified":"2026-08-06T16:31:50","modified_gmt":"2026-08-06T14:31:50","slug":"41-new-strain-lacticaseibacillus-paracasei-lpc-37","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/41-new-strain-lacticaseibacillus-paracasei-lpc-37\/","title":{"rendered":"41: New Strain: Lacticaseibacillus paracasei Lpc-37"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Research on&nbsp;<em>Lacticaseibacillus paracasei<\/em>&nbsp;Lpc-37 and its clinical Applications<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Lacticaseibacillus paracasei<\/em>&nbsp;Lpc-37 was isolated from a dairy product several decades ago and has since been extensively studied in both preclinical and clinical trials. These studies have investigated the strain either in isolation or in combination with other probiotic strains.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One relatively underexplored health aspect in scientific research where this strain has been evaluated is sleep quality. Two randomized placebo-controlled trials (RCTs) examining Lpc-37 as a monostrain showed a positive effect on sleep quality (1,2). These studies were conducted among students preparing for an exam and healthy adults. In both populations, a reduction in sleep disturbances was observed compared to the placebo group. Additionally, the same studies evaluated the effect on stress, with the first study (1) finding no significant differences, while the second study (2) reported a positive effect.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A second notable indication that has been investigated is autism, where Lpc-37 was administered as part of a formulation containing multiple probiotic strains and a prebiotic (3). Although this pilot study has limitations (including a small number of participants and a relatively high dropout rate), its findings are relevant. An improvement was observed on a scale quantifying the severity of autism spectrum disorder (ASD) symptoms. This is particularly significant, as interventions showing such an effect are rare. The study supports the concept that microbiome-targeted interventions may play a role in autism, aligning with recent research on the gut microbiome\u2019s role in autism, including a multi-cohort study published in Scientific Reports (4). To further explore these findings, we are organizing a webinar on this topic, where we will also discuss case studies from clinical practice. This&nbsp;<strong>thematic webinar on autism<\/strong>&nbsp;will take place on&nbsp;<strong>March 17<\/strong>&nbsp;(English) and&nbsp;<strong>April 1<\/strong>&nbsp;(German) from&nbsp;<strong>19:30-21:00 CET<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, a large-scale RCT with Lpc-37 as a monostrain demonstrated a positive effect on the prevention of diarrhea and fever (5), as well as on various other indications such as antibiotic-associated diarrhea, cognitive functions, and pathogens. For more information on this strain and the scientific evidence, please refer to the supplementary documentation via the i-icon next to this ingredient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do you want to read more insights?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You can follow us on LinkedIn:&nbsp;<a href=\"https:\/\/www.linkedin.com\/company\/microbiome-center\/\">https:\/\/www.linkedin.com\/company\/microbiome-center\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Or read previous insights flashes at:&nbsp;<a href=\"https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/\">https:\/\/dev.studioboszkers.nl\/microbiome-center\/en\/medici\/kennisflits\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.bbih.2023.100673\">https:\/\/doi.org\/10.1016\/j.bbih.2023.100673<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ynstr.2020.100277\">https:\/\/doi.org\/10.1016\/j.ynstr.2020.100277<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.phrs.2020.104784\">https:\/\/doi.org\/10.1016\/j.phrs.2020.104784<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41598-023-50601-7\">https:\/\/doi.org\/10.1038\/s41598-023-50601-7<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.9734\/EJNFS\/2014\/8280\">https:\/\/doi.org\/10.9734\/EJNFS\/2014\/8280<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Research on&nbsp;Lacticaseibacillus paracasei&nbsp;Lpc-37 and its clinical Applications Lacticaseibacillus paracasei&nbsp;Lpc-37 was isolated from a dairy product several decades ago and has since been extensively studied in both preclinical and clinical trials. These studies have investigated the strain either in isolation or in combination with other probiotic strains. One relatively underexplored health aspect in scientific research where [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[],"class_list":["post-227437","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>41: New Strain: Lacticaseibacillus paracasei Lpc-37 - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"41: New Strain: Lacticaseibacillus paracasei Lpc-37 - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Research on&nbsp;Lacticaseibacillus paracasei&nbsp;Lpc-37 and its clinical Applications Lacticaseibacillus paracasei&nbsp;Lpc-37 was isolated from a dairy product several decades ago and has since been extensively studied in both preclinical and clinical trials. 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