{"id":227421,"date":"2026-08-06T16:09:22","date_gmt":"2026-08-06T14:09:22","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227421"},"modified":"2026-08-06T16:09:28","modified_gmt":"2026-08-06T14:09:28","slug":"33-new-ingredient-new-questions","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/33-new-ingredient-new-questions\/","title":{"rendered":"33: New ingredient, new questions"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Bifidobacterium lactis HN019<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recently, a new building block has been added to the list of options that you can use in personalized microbiome treatments. This building block consists of the Bifidobacterium lactis HN019, an extensively studied probiotic strain that was originally isolated from yoghurt. Multiple high quality RCTs show that this strain is effective against periodontitis (1-3). In a meta-analysis of clinical studies, HN019 has also been effective in promoting cellular immunity in the elderly (4). This involves phagocytic capacity of polymorphonuclear cells (destroying invading pathogens via phagocytosis) and tumoricidal activity of natural killer cells (eliminating tumor cells). In addition, large clinical studies have shown that HN019 is effective in preventing respiratory tract infections and iron deficiency in children (5-7).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This strain has been investigated for other effects too, including constipation, flatulence, and anti-inflammatory effects. You can find all information about the available evidence for this strain on our web platform by clicking on the i-button behind this building block.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Updated Advice Aid questions<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">With the addition of the B. lactis HN019 building block, several new indications have been added to the Medical Background list. This includes periodontitis, cellular immunity, and iron deficiency. In addition, the question about bloating\/flatulence in the Complaints list has been split into two separate questions. Although these two complaints are related to each other, they are not the same and the evidence of different building blocks in fact warrants a distinction. For example, for B. lactis HN019 the evidence shows that is has an effect on flatulence, but not on bloating.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By constantly evaluating the evidence and the Advice Aid questions, Microbiome Center ensures a continuous process of improvement, so that you can provide the very best treatment for your patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1111\/jcpe.12995\">https:\/\/doi.org\/10.1111\/jcpe.12995<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0238425\">https:\/\/doi.org\/10.1371\/journal.pone.0238425<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00784-022-04744-y\">https:\/\/doi.org\/10.1007\/s00784-022-04744-y<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu9030191\">https:\/\/doi.org\/10.3390\/nu9030191<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0012164\">https:\/\/doi.org\/10.1371\/journal.pone.0012164<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2022.0041\">https:\/\/doi.org\/10.3920\/BM2022.0041<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1097\/MPG.0b013e3181d98e45\">https:\/\/doi.org\/10.1097\/MPG.0b013e3181d98e45<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Bifidobacterium lactis HN019 Recently, a new building block has been added to the list of options that you can use in personalized microbiome treatments. This building block consists of the Bifidobacterium lactis HN019, an extensively studied probiotic strain that was originally isolated from yoghurt. Multiple high quality RCTs show that this strain is effective against [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227421","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>33: New ingredient, new questions - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"33: New ingredient, new questions - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Bifidobacterium lactis HN019 Recently, a new building block has been added to the list of options that you can use in personalized microbiome treatments. This building block consists of the Bifidobacterium lactis HN019, an extensively studied probiotic strain that was originally isolated from yoghurt. 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