{"id":227417,"date":"2026-08-06T15:59:44","date_gmt":"2026-08-06T13:59:44","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227417"},"modified":"2026-08-06T15:59:51","modified_gmt":"2026-08-06T13:59:51","slug":"31-evidence-updates","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/31-evidence-updates\/","title":{"rendered":"31: Evidence updates"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Evidence is continuously updated<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In order to offer the best possible treatment options, Microbiome Center continuously updates the evidence of all available ingredients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A recent example is the addition of evidence for&nbsp;<em>Bacillus clausii&nbsp;<\/em>UBBC-07. New studies have been published about its effect on upper respiratory tract infections, prevention of radiation therapy induced mucositis, and ulcerative colitis (1-3). A well-conducted RCT with 90 children showed that, compared to placebo, treatment with&nbsp;<em>B. clausii&nbsp;<\/em>UBBC-07 led to a large reduction in the mean number, duration, and severity of upper respiratory tract infections (1). Another RCT investigated whether this strain can reduce side effects of radiation therapy of head and neck cancer patients, in particular mucositis (2). It was found that the time to onset of mucositis was longer, duration of mucositis was shorter, and, most prominently, that the severity of mucositis was substantially less. A third RCT in IBD patients showed a benefit of&nbsp;<em>B. clausii&nbsp;<\/em>UBBC-07 on disease activity score and markers of inflammation compared to placebo in ulcerative colitis patients but not in Crohn\u2019s disease patients. This shows the importance of making a distinction between these two different diseases within the IBD cluster.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Another example of a strain with recently added evidence is&nbsp;<em>Bacillus coagulans<\/em>&nbsp;Unique IS-2. This strain was investigated for its effect on ulcerative colitis too, with similar findings as the aforementioned&nbsp;<em>B. clausii&nbsp;<\/em>UBBC-07 study (4). Interestingly, there was already evidence that&nbsp;<em>B. coagulans<\/em>&nbsp;Unique IS-2 is effective in constipation, and a new well-conducted RCT confirms that this strain has a large effect on constipation (5).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These and other evidence updates are continuously processed and added to the Advice Aid, so that the suggested personalized preparations are always based on the best available knowledge and the most complete overview of the scientific evidence. All studies can be found under the i-button of each ingredient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2021.0187\">https:\/\/doi.org\/10.3920\/BM2021.0187<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ctarc.2022.100523\">https:\/\/doi.org\/10.1016\/j.ctarc.2022.100523<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.anaerobe.2022.102652\">https:\/\/doi.org\/10.1016\/j.anaerobe.2022.102652<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1101\/2021.07.18.21260556\">https:\/\/doi.org\/10.1101\/2021.07.18.21260556<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s12602-021-09855-8\">https:\/\/doi.org\/10.1007\/s12602-021-09855-8<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Evidence is continuously updated In order to offer the best possible treatment options, Microbiome Center continuously updates the evidence of all available ingredients. A recent example is the addition of evidence for&nbsp;Bacillus clausii&nbsp;UBBC-07. New studies have been published about its effect on upper respiratory tract infections, prevention of radiation therapy induced mucositis, and ulcerative colitis [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227417","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>31: Evidence updates - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"31: Evidence updates - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Evidence is continuously updated In order to offer the best possible treatment options, Microbiome Center continuously updates the evidence of all available ingredients. 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