{"id":227415,"date":"2026-08-06T15:56:29","date_gmt":"2026-08-06T13:56:29","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227415"},"modified":"2026-08-06T15:56:36","modified_gmt":"2026-08-06T13:56:36","slug":"30-vaginal-suppositories","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/30-vaginal-suppositories\/","title":{"rendered":"30: Vaginal suppositories"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>The role of the vaginal microbiome in vaginal complaints<\/strong>&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vaginal complaints are highly prevalent in the family doctor practice. A Dutch publication from 2002 states that 40% of interviewed women had vaginal discharge in the previous week (1). International research shows that, although there is large between-country variation, the prevalence of bacterial vaginosis ranges from 5-20% in Western countries (2).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Like the gut, skin, or lungs, the vagina has its own distinct microbiome and many vaginal complaints are linked to a disturbed vaginal microbiome. For example, the most important cause of abnormal vaginal discharge, bacterial vaginosis, is characterized by vaginal dysbiosis that precedes complaints (3). When bacterial vaginosis leads to complaints, it is typically treated with antibiotics, but this has a high relapse rate (2). This is not surprising, as antibiotics can disturb the vaginal microbiome even further.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to vaginal complaints, the vaginal microbiome plays a role in fertility. The chance on successful pregnancy is higher when there is a healthy,&nbsp;<em>Lactobacillus<\/em>-dominated vaginal microbiome (4,5).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Because many vaginal complaints are linked to vaginal dysbiosis, an intervention targeting the vaginal microbiome is desired. For this reason, Microbiome Center, together with the pharmacist and a number of doctors in our network, has developed vaginal suppositories. These contain three probiotic strains in high dose, including two&nbsp;<em>Lactobacillus&nbsp;<\/em><em>crispatus<\/em>&nbsp;strains. This bacterial species is strongly associated with a healthy vaginal microbiome (3). The suppositories can be prescribed online as a set of 30 pieces and are&nbsp;magistrally&nbsp;prepared by the pharmacist.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you want to learn more about the vaginal microbiome, its role in vaginal complaints such as bacterial vaginosis and vulvovaginal candidiasis and in fertility, and how vaginal suppositories may be used, you can join our online&nbsp;<strong>webinar<\/strong>&nbsp;(in Dutch)&nbsp;<strong>on April 20<\/strong><strong><sup>th<\/sup><\/strong>&nbsp;<strong>2023.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong>&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1.&nbsp;&nbsp;&nbsp;&nbsp;<a href=\"https:\/\/www.henw.org\/artikelen\/vaginale-klachten\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.henw.org\/artikelen\/vaginale-klachten<\/a>&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.&nbsp;&nbsp;&nbsp;&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.ejogrb.2019.12.035\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.ejogrb.2019.12.035<\/a>&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.&nbsp;&nbsp;&nbsp;&nbsp;<a href=\"https:\/\/doi.org\/10.3389\/fcimb.2021.631972\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fcimb.2021.631972<\/a>&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4.&nbsp;&nbsp;&nbsp;&nbsp;<a href=\"https:\/\/doi.org\/10.1093\/humrep\/dew026\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1093\/humrep\/dew026<\/a>&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5.&nbsp;&nbsp;&nbsp;&nbsp;<a href=\"https:\/\/doi.org\/10.7860\/JCDR\/2017\/28296.10417\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.7860\/JCDR\/2017\/28296.10417<\/a>&nbsp;&nbsp;<\/p>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The role of the vaginal microbiome in vaginal complaints&nbsp; Vaginal complaints are highly prevalent in the family doctor practice. A Dutch publication from 2002 states that 40% of interviewed women had vaginal discharge in the previous week (1). International research shows that, although there is large between-country variation, the prevalence of bacterial vaginosis ranges from [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227415","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>30: Vaginal suppositories - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"30: Vaginal suppositories - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"The role of the vaginal microbiome in vaginal complaints&nbsp; Vaginal complaints are highly prevalent in the family doctor practice. 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