{"id":227411,"date":"2026-08-06T15:52:01","date_gmt":"2026-08-06T13:52:01","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227411"},"modified":"2026-08-06T15:52:08","modified_gmt":"2026-08-06T13:52:08","slug":"28-new-ingredient-pasteurized-akkermansia-muciniphila","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/28-new-ingredient-pasteurized-akkermansia-muciniphila\/","title":{"rendered":"28: New ingredient: pasteurized Akkermansia muciniphila"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Pasteurized&nbsp;<em>Akkermansia muciniphila<\/em>, a postbiotic<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In approximately one in eight stool analyses&nbsp;<em>Akkermansia muciniphila<\/em>&nbsp;is extremely depleted (less than 1\u00d710<sup>5<\/sup>&nbsp;CFU\/g) and in a larger group it is substantially depleted. This is an indication of a disturbed mucus layer, which forms an important part of the gut barrier.&nbsp;<em>A. muciniphila<\/em>&nbsp;is known to enhance the integrity of the intestinal epithelial cells and the thickness of the mucus layer and participates in the host immune regulation, thereby promoting intestinal health (1). Interestingly, important parts of the beneficial effects of&nbsp;<em>A. muciniphila<\/em>&nbsp;can be traced back to Amuc_1100, a specific pili-like protein isolated from the outer membrane of&nbsp;<em>A. muciniphila<\/em>&nbsp;(2). This is why pasteurized&nbsp;<em>A. muciniphila<\/em>&nbsp;is as effective as live cells, as demonstrated in, amongst others, the one human study to date (3). Because&nbsp;<em>A. muciniphila<\/em>&nbsp;is pasteurized and thus the active ingredient does not consist of living bacteria, it is called a postbiotic (4).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The aforementioned RCT shows that supplementation with pasteurized&nbsp;<em>A. muciniphila<\/em>leads to lowering of insulin resistance as well as weight (and body fat) loss (3). This effect is supported by evidence from numerous animal studies, as shown for example in a systematic review of ten animal studies (5). These and other therapeutic effects (e.g. on colitis or allergies) are linked to its inflammation lowering and gut barrier restoring effects, as shown in both the RCT and many animal studies (3, and e.g. 6, 7). This includes stimulation of mucus production and increased mucus layer thickness (6).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As of February 1<sup>st<\/sup>, pasteurized&nbsp;<em>A. muciniphila<\/em>&nbsp;is available as new building block that you can select as ingredient for MyOwnBlend. More information on this postbiotic and its effects can be found under the (i)-button on our platform.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We organize a webinar to provide further backgrounds on the role of&nbsp;<em>A. muciniphila<\/em>&nbsp;in health and disease on February 23<sup>rd<\/sup>&nbsp;and March 21<sup>st<\/sup>&nbsp;from 19:30-21:00h. If you are interested to join, you can reply to this e-mail, including which date you prefer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1111\/1751-7915.13410\">https:\/\/doi.org\/10.1111\/1751-7915.13410<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0173004\">https:\/\/doi.org\/10.1371\/journal.pone.0173004<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41591-019-0495-2\">https:\/\/doi.org\/10.1038\/s41591-019-0495-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41575-021-00440-6\">https:\/\/doi.org\/10.1038\/s41575-021-00440-6<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/microorganisms9051098\">https:\/\/doi.org\/10.3390\/microorganisms9051098<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.12182\/20220160304\">https:\/\/doi.org\/10.12182\/20220160304<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fmicb.2019.02259\">https:\/\/doi.org\/10.3389\/fmicb.2019.02259<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Pasteurized&nbsp;Akkermansia muciniphila, a postbiotic In approximately one in eight stool analyses&nbsp;Akkermansia muciniphila&nbsp;is extremely depleted (less than 1\u00d7105&nbsp;CFU\/g) and in a larger group it is substantially depleted. This is an indication of a disturbed mucus layer, which forms an important part of the gut barrier.&nbsp;A. muciniphila&nbsp;is known to enhance the integrity of the intestinal epithelial cells [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227411","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>28: New ingredient: pasteurized Akkermansia muciniphila - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"28: New ingredient: pasteurized Akkermansia muciniphila - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Pasteurized&nbsp;Akkermansia muciniphila, a postbiotic In approximately one in eight stool analyses&nbsp;Akkermansia muciniphila&nbsp;is extremely depleted (less than 1\u00d7105&nbsp;CFU\/g) and in a larger group it is substantially depleted. 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