{"id":227409,"date":"2026-08-06T15:50:09","date_gmt":"2026-08-06T13:50:09","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227409"},"modified":"2026-08-06T15:50:16","modified_gmt":"2026-08-06T13:50:16","slug":"27-new-strain-effective-in-acne-and-caries","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/27-new-strain-effective-in-acne-and-caries\/","title":{"rendered":"27: New strain effective in acne and caries"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>ew strain:&nbsp;<em>Lacticaseibacillus rhamnosus<\/em>&nbsp;SP1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">When we encounter interesting ingredients for microbiome treatments, we try to make these available for you so that the possibilities to treat patients continue to expand. We have now added the strain&nbsp;<em>Lacticaseibacillus rhamnosus<\/em>&nbsp;SP1 which has been studied, among others, for its effect on acne and on caries. Importantly, many effects are strain-specific and there are many strains of the&nbsp;<em>L. rhamnosus<\/em>&nbsp;species. It must be noted that not all strains of this species can be expected to have the same effect as this strain named SP1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A small but well-conducted RCT with&nbsp;<em>L. rhamnosus<\/em>&nbsp;SP1 shows that it leads to improved or markedly improved acne symptoms compared to placebo (1). In addition, this study showed that the use of&nbsp;<em>L. rhamnosus<\/em>&nbsp;SP1 induced a clear reduction of expression of insulin-like growth factor 1 (IGF1) in skin samples of the probiotic group compared to placebo, which is evidence for an effect on insulin signaling. Indeed, accumulating evidence shows that disturbed gut microbiota is associated with acne, partly due to its effect on insulin signaling, but clinical trials with probiotic interventions are scarce (2). This in itself makes&nbsp;<em>L. rhamnosus<\/em>&nbsp;SP1 an interesting addition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Another study conducted with this strain is a large RCT (and a subgroup analysis thereof) that investigated the effect of this strain on the prevention of caries in preschool children. The results shows that, compared to placebo,&nbsp;<em>L. rhamnosus<\/em>&nbsp;SP1 effectively prevents caries (3,4). Another RCT on oral health provides evidence for an effect on Candida-associated denture stomatitis (5). This study also provides direct evidence for an inhibiting effect on (oral) candida.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">More information on this strain and its effects can be found under the (i)-button on our platform.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2016.0089\">https:\/\/doi.org\/10.3920\/BM2016.0089<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/microorganisms10071303\">https:\/\/doi.org\/10.3390\/microorganisms10071303<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/0022034515623935\">https:\/\/doi.org\/10.1177\/0022034515623935<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00784-020-03712-8\">https:\/\/doi.org\/10.1007\/s00784-020-03712-8<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/adj.12692\">https:\/\/doi.org\/10.1111\/adj.12692<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>ew strain:&nbsp;Lacticaseibacillus rhamnosus&nbsp;SP1 When we encounter interesting ingredients for microbiome treatments, we try to make these available for you so that the possibilities to treat patients continue to expand. We have now added the strain&nbsp;Lacticaseibacillus rhamnosus&nbsp;SP1 which has been studied, among others, for its effect on acne and on caries. Importantly, many effects are strain-specific [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227409","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>27: New strain effective in acne and caries - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"27: New strain effective in acne and caries - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"ew strain:&nbsp;Lacticaseibacillus rhamnosus&nbsp;SP1 When we encounter interesting ingredients for microbiome treatments, we try to make these available for you so that the possibilities to treat patients continue to expand. 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