{"id":227405,"date":"2026-08-06T15:40:48","date_gmt":"2026-08-06T13:40:48","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227405"},"modified":"2026-08-06T15:40:55","modified_gmt":"2026-08-06T13:40:55","slug":"25-l-plantarum-dr7-arthritis-and-microbial-butyrate","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\/","title":{"rendered":"25: L. plantarum DR7, arthritis and microbial butyrate"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>New strain:&nbsp;<em>Lactiplantibacillus plantarum<\/em>&nbsp;DR7<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Another strain has been added to the list from which you can select, the&nbsp;<em>L. plantarum<\/em>&nbsp;DR7. This strain has been isolated from fresh cow\u2019s milk in Malaysia (1). It has anti-inflammatory effects, shown both in preclinical and clinical studies (2-4), and stimulates AMPK activity (5). AMPK (adenosine 5\u2032-monophosphate-activated protein kinase) is a cellular energy sensor and lowered AMPK activity is linked to insulin resistance, amongst others (6). In fact, one of the mechanisms of action of the well-known antidiabetic drug metformin is via activation of AMPK (7). Treatment with metformin has effects on many conditions, including reducing anxiety, which is thought to be linked to its effect on AMPK (8). Interestingly, a high quality RCT shows that this AMPK-stimulating&nbsp;<em>L. plantarum<\/em>&nbsp;DR7 strain indeed reduces stress and anxiety (4). In addition, this strain can inhibit respiratory pathogens&nbsp;<em>in vitro<\/em>&nbsp;and has been shown to be efficacious in reducing incidence and severity of upper respiratory tract infections in a RCT (4,9). Additional evidence and information about this strain can be found at the description of this ingredient in our system.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rheumatoid arthritis linked to low levels of microbial butyrate&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A very sophisticated study, published in Science Advances in February this year, has found that intestinal butyrate-metabolizing species play a role in rheumatoid arthritis (10). Here, the term \u201cbutyrate-metabolizing\u201d refers to both butyrate production as well as butyrate consumption, and the investigators found that the number of butyrate-consuming species was much higher in treatment-na\u00efve rheumatoid arthritis patients than in healthy controls. In fact, no less than 51 of 55 of the rheumatoid arthritis-associated butyrate metabolizers were butyrate consumers, 46 of which were enriched in rheumatoid arthritis patients. This suggests that in rheumatoid arthritis the level of microbial butyrate available to the host is substantially decreased. Next, the researchers validated the finding of the skewed butyrate producers\/consumers ratio in an independent cohort. In this second cohort it was also shown that indeed both fecal and serum levels of butyrate were decreased in rheumatoid arthritis patients compared to healthy controls. Finally, the investigators showed that supplementation of butyrate in an animal model of arthritis led to a substantial lower arthritis incidence (11% vs. 85%) and severity compared to controls. Together, these findings provide strong evidence for a role of butyrate-metabolizing species in rheumatoid arthritis. This suggests that interventions with butyrate-producing species such as&nbsp;<em>Anaerobutyricum soehngenii<\/em>&nbsp;or&nbsp;<em>Clostridium butyricum<\/em>, both available via our platform, may be beneficial.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1089\/jmf.2007.0144\">https:\/\/doi.org\/10.1089\/jmf.2007.0144<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2019.0200\">https:\/\/doi.org\/10.3920\/BM2019.0200<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2018.0135\">https:\/\/doi.org\/10.3920\/BM2018.0135<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3168\/jds.2018-16103\">https:\/\/doi.org\/10.3168\/jds.2018-16103<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2019.0058\">https:\/\/doi.org\/10.3920\/BM2019.0058<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1152\/ajpendo.1999.277.1.E1\">https:\/\/doi.org\/10.1152\/ajpendo.1999.277.1.E1<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00125-017-4342-z\">https:\/\/doi.org\/10.1007\/s00125-017-4342-z<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s11011-015-9677-x\">https:\/\/doi.org\/10.1007\/s11011-015-9677-x<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/microorganisms9030528\">https:\/\/doi.org\/10.3390\/microorganisms9030528<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/sciadv.abm1511\">https:\/\/doi.org\/10.1126\/sciadv.abm1511<\/a>\u00a0<\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>New strain:&nbsp;Lactiplantibacillus plantarum&nbsp;DR7 Another strain has been added to the list from which you can select, the&nbsp;L. plantarum&nbsp;DR7. This strain has been isolated from fresh cow\u2019s milk in Malaysia (1). It has anti-inflammatory effects, shown both in preclinical and clinical studies (2-4), and stimulates AMPK activity (5). AMPK (adenosine 5\u2032-monophosphate-activated protein kinase) is a cellular [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227405","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>25: L. plantarum DR7, arthritis and microbial butyrate - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"25: L. plantarum DR7, arthritis and microbial butyrate - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"New strain:&nbsp;Lactiplantibacillus plantarum&nbsp;DR7 Another strain has been added to the list from which you can select, the&nbsp;L. plantarum&nbsp;DR7. This strain has been isolated from fresh cow\u2019s milk in Malaysia (1). It has anti-inflammatory effects, shown both in preclinical and clinical studies (2-4), and stimulates AMPK activity (5). AMPK (adenosine 5\u2032-monophosphate-activated protein kinase) is a cellular [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/microbiome-center.nl\/en\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\/\" \/>\n<meta property=\"og:site_name\" content=\"Microbiome Center\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-06T13:40:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-06T13:40:55+00:00\" \/>\n<meta name=\"author\" content=\"Henk Duinkerken\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Henk Duinkerken\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/\"},\"author\":{\"name\":\"Henk Duinkerken\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/#\\\/schema\\\/person\\\/5cde9902b8b7f8f1bd00c360f00ac625\"},\"headline\":\"25: L. plantarum DR7, arthritis and microbial butyrate\",\"datePublished\":\"2026-08-06T13:40:48+00:00\",\"dateModified\":\"2026-08-06T13:40:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/\"},\"wordCount\":469,\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/\",\"url\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/\",\"name\":\"25: L. plantarum DR7, arthritis and microbial butyrate - Microbiome Center\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/#website\"},\"datePublished\":\"2026-08-06T13:40:48+00:00\",\"dateModified\":\"2026-08-06T13:40:55+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/#\\\/schema\\\/person\\\/5cde9902b8b7f8f1bd00c360f00ac625\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/25-l-plantarum-dr7-arthritis-and-microbial-butyrate\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"25: L. plantarum DR7, arthritis and microbial butyrate\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/\",\"name\":\"Microbiome Center\",\"description\":\"Nieuw licht op chronische klachten\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/#\\\/schema\\\/person\\\/5cde9902b8b7f8f1bd00c360f00ac625\",\"name\":\"Henk Duinkerken\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/microbiome-center.nl\\\/wp-content\\\/litespeed\\\/avatar\\\/d28949657f11f375a56b5f2f9bfa8d15.jpg?ver=1787561796\",\"url\":\"https:\\\/\\\/microbiome-center.nl\\\/wp-content\\\/litespeed\\\/avatar\\\/d28949657f11f375a56b5f2f9bfa8d15.jpg?ver=1787561796\",\"contentUrl\":\"https:\\\/\\\/microbiome-center.nl\\\/wp-content\\\/litespeed\\\/avatar\\\/d28949657f11f375a56b5f2f9bfa8d15.jpg?ver=1787561796\",\"caption\":\"Henk Duinkerken\"},\"url\":\"https:\\\/\\\/microbiome-center.nl\\\/en\\\/author\\\/henk-duinkerken\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"25: L. plantarum DR7, arthritis and microbial butyrate - Microbiome Center","robots":{"index":"noindex","follow":"follow"},"og_locale":"en_US","og_type":"article","og_title":"25: L. plantarum DR7, arthritis and microbial butyrate - Microbiome Center","og_description":"New strain:&nbsp;Lactiplantibacillus plantarum&nbsp;DR7 Another strain has been added to the list from which you can select, the&nbsp;L. plantarum&nbsp;DR7. 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