{"id":227389,"date":"2026-08-06T15:21:17","date_gmt":"2026-08-06T13:21:17","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227389"},"modified":"2026-08-06T15:21:23","modified_gmt":"2026-08-06T13:21:23","slug":"17-new-strains-mechanisms","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/17-new-strains-mechanisms\/","title":{"rendered":"17: New strains, mechanisms"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Two new strains in one building block<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We recently added a new building block that this time consists of two new strains: an Enterococcus faecium and a Bacillus subtilis strain. These two strains are the active ingredients of a drug that has been marketed and extensively researched in Asia. For example, a meta-analysis of 53 RCTs shows that this combination of strains is effective in ulcerative colitis (1). This meta-analysis also provides direct evidence for an effect on inflammation. RCTs also show evidence for an effect on abdominal pain and IBS (2,3), and small intestinal bacterial overgrowth (SIBO)(4), and a retrospective study provides evidence for an effect in antibiotic-associated diarrhea (5). Other evidence and information about this building block can be found in the description of this ingredient in our system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Important mechanisms behind chronic diseases<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the previous flash of knowledge, it was discussed that almost 10 million Dutch people have one or more chronic conditions. Two important mechanisms in chronic diseases are insulin resistance and systemic low-grade inflammation. These mechanisms are best known in the metabolic syndrome and type 2 diabetes, but it doesn\u2019t stop there. They play a role in (almost) all chronic conditions. To illustrate, some (perhaps unexpected) examples of this are depression (6-8), rheumatism (9,10), and ME\/CFS (11,12). Both insulin resistance and systemic low-grade inflammation are directly related to the microbiome (13-16). It can therefore be concluded that it is useful to take these two important mechanisms and the role of the microbiome into account in the therapeutic regimen in all chronic diseases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.12998\/wjcc.v6.i15.961\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.12998\/wjcc.v6.i15.961<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/nmo.12544\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1111\/nmo.12544<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/www.kjg.or.kr\/journal\/view.html?uid=3648&amp;vmd=Full\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.kjg.or.kr\/journal\/view.html?uid=3648&amp;vmd=Full<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3748\/wjg.v25.i17.2110\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3748\/wjg.v25.i17.2110<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1097\/MD.0000000000020631\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1097\/MD.0000000000020631<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.01.016\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.expneurol.2019.01.016<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fpsyt.2019.00057\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fpsyt.2019.00057<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1017\/S0033291719001454\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1017\/S0033291719001454<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/art.38986\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1002\/art.38986<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/nrrheum.2016.136\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1038\/nrrheum.2016.136<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1073\/pnas.1607571113\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1073\/pnas.1607571113<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fnbeh.2018.00078\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fnbeh.2018.00078<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.arr.2017.10.003\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.ar2017.10.003<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/0884533615609896\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1177\/0884533615609896<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.cmet.2017.09.008\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.cmet.2017.09.008<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.4049\/jimmunol.1601621\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.4049\/jimmunol.1601621<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Two new strains in one building block We recently added a new building block that this time consists of two new strains: an Enterococcus faecium and a Bacillus subtilis strain. These two strains are the active ingredients of a drug that has been marketed and extensively researched in Asia. For example, a meta-analysis of 53 [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227389","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>17: New strains, mechanisms - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"17: New strains, mechanisms - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Two new strains in one building block We recently added a new building block that this time consists of two new strains: an Enterococcus faecium and a Bacillus subtilis strain. These two strains are the active ingredients of a drug that has been marketed and extensively researched in Asia. 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