{"id":227372,"date":"2026-08-06T14:33:24","date_gmt":"2026-08-06T12:33:24","guid":{"rendered":"https:\/\/microbiome-center.nl\/?p=227372"},"modified":"2026-08-06T14:33:30","modified_gmt":"2026-08-06T12:33:30","slug":"15-new-ingredient-psoriasis","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/15-new-ingredient-psoriasis\/","title":{"rendered":"15: New ingredient; psoriasis"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>New ingredient<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At the request of several colleagues, we have added 2\u2032-fucosyllactose (2\u2019FL) to the list of ingredients for you to choose from. 2\u2019FL is a so-called \u2018human milk oligosaccharide\u2019 and is naturally present in breast milk. Such breast milk oligosaccharides contribute to the development of the microbiome and the tuning of the immune system. These effects are thought to occur in adults as well, and 2\u2032-fucosyllactose has been found to be safe in adults (1). Interestingly, there is preclinical evidence that Akkermansia muciniphila can grow on 2\u2019FL (2-4), suggesting that 2\u2019FL is one of the few compounds that can stimulate this important bacterial species. Akkermansia muciniphila is a bacterial species that is important for health, which breaks down mucin and thus stimulates a healthy intestinal wall and is often greatly reduced in diseases (5,6). It is perhaps therefore not unexpected that preclinical evidence shows that 2\u2019FL improves intestinal barrier function (7.8). Furthermore, there is some evidence from human studies for an effect on anti-inflammatory (9), allergies (10), and respiratory infections (11). Other evidence and information can be found in the description of this ingredient in our system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Role of gut microbiome in psoriasis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although psoriasis is known as a skin disease, there are several indications that the gut microbiome plays a role (12,13). This is probably related to the fact that psoriasis has a compromised immune system and low-grade inflammation (14,15). Many of the comorbidities found in psoriasis (such as type 2 diabetes, non-alcoholic fatty liver, depression, cardiovascular disease, and Crohn\u2019s disease (14,15)) are related to the core factors of the metabolic syndrome: systemic low-grade inflammation and insulin resistance. The latter is also found in psoriasis (16,17). The gut microbiome is known to play an important role in these underlying mechanisms, including through its effect on gut permeability. This fits with the observation that gut barrier function is impaired in psoriasis (18). All of this suggests that microbiome therapy such as probiotics may be of benefit in psoriasis. Indeed, pilot studies show beneficial effects on inflammatory markers and symptom severity in psoriasis patients (19,20).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1017\/S0007114516003354\">https:\/\/doi.org\/10.1017\/S0007114516003354<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3920\/BM2016.0185\">https:\/\/doi.org\/10.3920\/BM2016.0185<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu12051284\">https:\/\/doi.org\/10.3390\/nu12051284<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41598-020-71113-8\">https:\/\/doi.org\/10.1038\/s41598-020-71113-8<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.26355\/eurrev_201909_19024\">https:\/\/doi.org\/10.26355\/eurrev_201909_19024<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.micpath.2016.02.005\">https:\/\/doi.org\/10.1016\/j.micpath.2016.02.005<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fcimb.2018.00372\">https:\/\/doi.org\/10.3389\/fcimb.2018.00372<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu12092808\">https:\/\/doi.org\/10.3390\/nu12092808<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3945\/jn.116.236919\">https:\/\/doi.org\/10.3945\/jn.116.236919<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00394-016-1180-6\">https:\/\/doi.org\/10.1007\/s00394-016-1180-6<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1097\/MPG.0000000000001520\">https:\/\/doi.org\/10.1097\/MPG.0000000000001520<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.berh.2020.101494\">https:\/\/doi.org\/10.1016\/j.berh.2020.101494<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/pathogens9060463\">https:\/\/doi.org\/10.3390\/pathogens9060463<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(14)61909-7\">https:\/\/doi.org\/10.1016\/S0140-6736(14)61909-7<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.3390\/ijms20061475\">https\/\/doi.org\/10.3390\/ijms20061475<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.3390\/ijerph15071486\">https\/\/doi.org\/10.3390\/ijerph15071486\u00a0<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.1016\/j.jaad.2015.01.004\">https\/\/doi.org\/10.1016\/j.jaad.2015.01.004\u00a0<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.3390\/microorganisms7110550\">https\/\/doi.org\/10.3390\/microorganisms7110550<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.4161\/gmic.25487\">https\/\/doi.org\/10.4161\/gmic.25487<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/https\/\/doi.org\/10.2340\/00015555-3305\">https\/\/doi.org\/10.2340\/00015555-3305<\/a><\/li>\n<\/ol>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>New ingredient At the request of several colleagues, we have added 2\u2032-fucosyllactose (2\u2019FL) to the list of ingredients for you to choose from. 2\u2019FL is a so-called \u2018human milk oligosaccharide\u2019 and is naturally present in breast milk. Such breast milk oligosaccharides contribute to the development of the microbiome and the tuning of the immune system. [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227372","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>15: New ingredient; psoriasis - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"15: New ingredient; psoriasis - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"New ingredient At the request of several colleagues, we have added 2\u2032-fucosyllactose (2\u2019FL) to the list of ingredients for you to choose from. 2\u2019FL is a so-called \u2018human milk oligosaccharide\u2019 and is naturally present in breast milk. Such breast milk oligosaccharides contribute to the development of the microbiome and the tuning of the immune system. 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