{"id":227139,"date":"2026-07-28T12:03:32","date_gmt":"2026-07-28T10:03:32","guid":{"rendered":"https:\/\/microbiome-center.nl\/4-depression\/"},"modified":"2026-08-06T15:09:35","modified_gmt":"2026-08-06T13:09:35","slug":"4-depression","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/4-depression\/","title":{"rendered":"4: Depression"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\">Advice Aid; product information update<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">After some technical challenges, all descriptions and references of the supplements and magisterial ingredients are now completed. You can find these by clicking on the (i) next to a product or ingredient in the Advice Aid or on the Prescription page. The description provides a summary of all studies that have been done with the product or ingredient in question, including the associated references.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Advice Aid has also been further improved. The proposed quantities of the pharmaceutical ingredients now also take into account the minimum and maximum daily dose for each ingredient. It remains unchanged that the outcome of the Advice Aid is based on the completed scores for the various indications (complaints, medical background, and lab results) on the one hand, and on the strength of the evidence of the products\/ingredients for these indications on the other. In the new version of the Advice Aid, a more refined gradation has also been made for the strength of the evidence, which has been weighted in a systematic (GRADE-inspired manner [1]). We are currently working hard to make the evidence scores visible to you in the next version of the Advice Aid, so that you can even better trace what the advice is based on.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Probiotics may be useful for depression<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years, it has become clear that the microbiome plays a role in mood and depression; there is talk of the gut-brain axis. There are relationships with the quality of life ie. depression and the composition, structure, and function of the microbiome [2,3]. Fecal transplantation from patients with major depression disorder (MDD) to mice or rats results in behaviors associated with depression [4,5]. Clinical studies have shown that interventions with probiotics can reduce depression [6-8].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Royal interest in the microbiome<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Palace symposium \u2018The Microbiome\u2019 took place on Tuesday 26 November, attended by King Willem-Alexander and Princess Beatrix [9]. Speakers were Martin Blaser, director of the Human Microbiome Program, and Professor Max Nieuwdorp, internist-endocrinologist and pioneer in fecal transplant research. Both lectures can be listened to [9]. At the highest level, too, attention is now being paid to the importance of the microbiome for health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/The_Grading_of_Recommendations_Assessment,_Development_and_Evaluation_(GRADE)_approach\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/en.wikipedia.org\/wiki\/The_Grading_of_Recommendations_Assessment,_Development_and_Evaluation_(GRADE)_approach<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/bies.201800027\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1002\/bies.201800027<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41564-018-0337-x\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1038\/s41564-018-0337-x<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/mp.2016.44\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1038\/mp.2016.44<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jpsychires.2016.07.019\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.jpsychires.2016.07.019<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.nut.2015.09.003\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.nut.2015.09.003<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.29219\/fnr.v62.1218\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.29219\/fnr.v62.1218<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.clnu.2018.04.010\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.clnu.2018.04.010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.paleisamsterdam.nl\/paleissymposium\/paleissymposium-the-microbiome\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.paleisamsterdam.nl\/paleissymposium\/paleissymposium-the-microbiome\/<\/a><\/li>\n<\/ul>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Advice Aid; product information update After some technical challenges, all descriptions and references of the supplements and magisterial ingredients are now completed. You can find these by clicking on the (i) next to a product or ingredient in the Advice Aid or on the Prescription page. The description provides a summary of all studies that [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[106],"class_list":["post-227139","post","type-post","status-publish","format-standard","hentry","category-uncategorized","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>4: Depression - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"4: Depression - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Advice Aid; product information update After some technical challenges, all descriptions and references of the supplements and magisterial ingredients are now completed. 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