{"id":227110,"date":"2026-07-28T11:51:24","date_gmt":"2026-07-28T09:51:24","guid":{"rendered":"https:\/\/microbiome-center.nl\/46-the-microbiome-center-method-now-peer-reviewed-and-published\/"},"modified":"2026-07-28T11:54:45","modified_gmt":"2026-07-28T09:54:45","slug":"46-the-microbiome-center-method-now-peer-reviewed-and-published","status":"publish","type":"post","link":"https:\/\/microbiome-center.nl\/en\/46-the-microbiome-center-method-now-peer-reviewed-and-published\/","title":{"rendered":"46: The Microbiome Center Method: Now Peer-Reviewed and Published"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n\n<p class=\"wp-block-paragraph\"><strong>Looking for the best treatment for a patient<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">Every healthcare provider strives to provide the best treatment for each patient. However, determining what is \"the best\" treatment can be tricky \u2013 especially in patients with multimorbidity, which is the most common situation today (1). In many modern approaches to medical decision-making, scientific evidence plays a central role. There are various frameworks that help healthcare providers to use evidence when choosing the most appropriate treatment. Two of the best known are Evidence-Based Medicine (EBM) and Personalized Medicine (PM).    <\/p>\n\n<p class=\"wp-block-paragraph\">Both EBM and PM have their own strengths, but also limitations. For example, EBM uses randomized controlled trials (RCTs) as the gold standard for research, as this is the best method to eliminate most forms of bias (2). At the same time, RCTs are not easily translated to patients in daily practice and only describe the average effect, which does not predict the effect in the individual patient (3,4).  <\/p>\n\n<p class=\"wp-block-paragraph\">These various limitations make it difficult to fully apply the EBM or PM approach in clinical practice. Because chronic patients each have a unique profile, and because the gut microbiome is both highly individual and involved in many chronic conditions, Microbiome Center saw a great need for a new approach. <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>The Microbiome Center method: now peer-reviewed and published<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">In 2019, Microbiome Center, together with a collaboration of experts from immunology, pharmacology, computational sciences, citizen science and clinical practice, developed a methodology to combine the strengths of EBM and PM. Since then, we have implemented, refined, improved and further expanded this method. As a practitioner, you will encounter this when you use our advice tool. This is not just a set of questionnaires and buttons, it is much more than that: it is a concrete elaboration of an extensive and carefully developed philosophy and scientific approach.   <\/p>\n\n<p class=\"wp-block-paragraph\">Recently, the philosophy and scientific method behind our approach have been peer-reviewed and published in a scientific article. The article was written together with several coauthors from various universities and institutes and has been published in the scientific journal Beneficial Microbes (5). The article discusses the different strengths and pitfalls of the EBM and PM methods, and places them in a broader perspective from the philosophy of science to integrate both paradigms. The new approach, called Evidence-Based Personalized Medicine (EBPM), is based on the philosophical worldview known as pragmatism.   <\/p>\n\n<p class=\"wp-block-paragraph\">With this publication, the fundamental approach that Microbiome Center uses is now peer-reviewed and recognized as a solid and innovative method of treating patients.<\/p>\n\n<p class=\"wp-block-paragraph\">References:<\/p>\n\n<p class=\"wp-block-paragraph\">1. https:\/\/doi.org\/10.1001\/jama.2012.5265<\/p>\n\n<p class=\"wp-block-paragraph\">2. https:\/\/doi.org\/10.1016\/j.cmet.2018.02.017<\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1093\/ije\/dyp174\">https:\/\/doi.org\/10.1093\/ije\/dyp174<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/miguelhernan.org\/whatifbook\">https:\/\/miguelhernan.org\/whatifbook<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1163\/18762891-bja00110\">https:\/\/doi.org\/10.1163\/18762891-bja00110<\/a><\/p>\n<div class=\"et_pb_section_0 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_0 et_pb_row et_flex_row\"><div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Looking for the best treatment for a patient Every healthcare provider strives to provide the best treatment for each patient. However, determining what is &#8220;the best&#8221; treatment can be tricky \u2013 especially in patients with multimorbidity, which is the most common situation today (1). In many modern approaches to medical decision-making, scientific evidence plays a [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"doelgroep":[],"class_list":["post-227110","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>46: The Microbiome Center Method: Now Peer-Reviewed and Published - Microbiome Center<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"46: The Microbiome Center Method: Now Peer-Reviewed and Published - Microbiome Center\" \/>\n<meta property=\"og:description\" content=\"Looking for the best treatment for a patient Every healthcare provider strives to provide the best treatment for each patient. However, determining what is &#8220;the best&#8221; treatment can be tricky \u2013 especially in patients with multimorbidity, which is the most common situation today (1). 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