{"id":225762,"date":"2026-06-26T16:57:04","date_gmt":"2026-06-26T14:57:04","guid":{"rendered":"https:\/\/microbiome-center.nl\/aandoeningen\/intestinal-disorders\/"},"modified":"2026-06-30T21:33:44","modified_gmt":"2026-06-30T19:33:44","slug":"intestinal-disorders","status":"publish","type":"aandoeningen","link":"https:\/\/microbiome-center.nl\/en\/aandoeningen\/intestinal-disorders\/","title":{"rendered":"Intestinal disorders"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n<div class=\"et_pb_section_0 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_0 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_heading_0 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h1 class=\"et_pb_module_header\">Intestinal disorders<\/h1><\/div><\/div>\n\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p><span data-metadata=\"<!--(figmeta)eyJmaWxlS2V5IjoiN2RYaVBJUWFIeFVVYUdZVllKZTdpNSIsInBhc3RlSUQiOjY3NjY2NTU1MSwiZGF0YVR5cGUiOiJzY2VuZSIsImVudmlyb25tZW50Ijoid3d3LmZpZ21hLmNvbSIsInNlbGVjdGVkTm9kZURhdGEiOiIzNTA3OjQzNjF8MzF8MCJ9Cg==(\/figmeta)-->\" style=\"caret-color: #000000; color: #000000;\"><\/span>Impression of the publications on the relevance of the microbiome<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_1 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_1 et_pb_row et_grid_row\">\n<div class=\"et_pb_column_1 et_pb_column et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_heading_1 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">Inflammatory bowel disease (IBD)<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>These include Crohn's disease and ulcerative colitis (1). The exact cause of these diseases is not known. The common view is that these diseases are the result of an exaggerated immune response to microorganisms in the gut, triggered by a combination of genetic predisposition and environmental factors (2). Interestingly, the identified risk-increasing genes are often involved in the recognition of and response to bacteria, and the functioning of the intestinal wall (2). The composition of the microbiome is altered in IBD patients and the absence of certain commensal bacterial species (especially species that make short-chain fatty acids) and the presence of pathogenic species correlates with disease activity (3,4). In addition, unlike healthy subjects, the composition of the microbiome is not stable over time, even in patients who are in remission (5). So it seems reasonable to say that there is something drastically wrong in the interaction between the immune system and the microbiome in IBD. Modification of the microbiome seems to lead to disease remission, as shown by a study in which 'poo transplantation' was used (6).       <\/p>\n<\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_2 et_pb_column et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_heading_2 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">Irritable bowel syndrome (IBS)<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_2 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>This is also called irritable bowel syndrome or spastic bowel. IBS is common in Western countries; Between 10% and 20% of the population suffers from this (7). It is therefore one of the most researched disorders. The exact cause is unknown and several factors are mentioned, including a disturbed communication between brain and gut, hypersensitivity to certain foods, low-grade inflammation (8), and a disturbed microbiome. A strong indication that a disturbed microbiome plays a role is the fact that many cases of the disease are preceded by acute intestinal infection by a bacterium, parasite, or sometimes a virus (7,8). Antibiotic use also seems to be a risk factor for the development of IBS. A second indication of a role of the microbiome is that various studies have found reduced diversity and its composition changed (9). Sterile laboratory animals colonized with faeces from IBS patients show different gut physiology (such as slower flow and increased pain sensitivity) compared to colonization with feces from healthy humans (7). A final clue to the role of the microbiome in IBS comes from the observation that influencing the microbiome with probiotics leads to symptom relief in many cases. Although one form of probiotic is not the same as another (each bacterial species and even strain has different effects) and it is therefore important to be careful not to lump clinical studies together, several meta-analyses have been published that show that certain types of probiotics lead to a reduction in symptoms in some patients (10, 11, 12).         <\/p>\n<\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_3 et_pb_column et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_heading_3 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">Chronic diarrhea<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_3 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>About one in 20 people suffer from this complaint, with about 40% of the cases involving the elderly (60+) (13). In some of these patients, chronic diarrhea is the result of a condition such as IBD, IBS, or celiac disease, but that is not the case for every patient with chronic diarrhea. Chronic diarrhoea can have a wide range of causes, and it is important to find the right cause for proper treatment (13). Some of these causes, such as parasite infection, poor digestion, bacterial disruption in the small intestine, or food intollerance, are undeniably related to the microbiome, given its normal function. In patients whose chronic diarrhea is unknown, the composition and distribution of the microbiome in stool samples has been shown to differ from healthy participants (14). Moreover, treatment with a probiotic causes little or no change in microbiome properties, nor in symptoms or bowel movements in healthy participants, while it leads to clear changes and a decrease in symptoms in patients (14). Even in patients for whom the cause of diarrhoea is known (e.g. IBD, infection with pathogenic bacteria, or antibiotic use), active modification of the microbiome by means of probiotics has been shown to lead to improvements (15), which is a clear indication of the involvement of the microbiome in such cases of chronic diarrhoea.      <\/p>\n<\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_4 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_heading_4 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">References<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_4 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>1. Clemente JC, Manasson J, Scher JU. The role of the gut microbiome in systemic inflammatory disease. BMJ. 2018; 360:j5145. <br \/>2. Matsuoka K, Kanai T. The gut microbiota and inflammatory bowel disease. Semin Immunopathol. 2015; 37:47\u201355. <br \/>3. Machiels K, Joossens M, Sabino J, Preter VD, Arijs I, Eeckhaut V, Ballet V, Claes K, Immerseel FV, Verbeke K, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014; 63:1275\u201383. <br \/>4. Forbes JD, Van Domselaar G, Bernstein CN. The Gut Microbiota in Immune-Mediated Inflammatory Diseases. Front Microbiol [Internet]. 2016 [cited 2018 Jan 14];7. Available from: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4939298\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4939298\/<\/a><br \/>5. Martinez C, Antolin M, Santos J, Torrejon A, Casellas F, Borruel N, Guarner F, Malagelada J-R. Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission. Am J Gastroenterol. 2008;103:643. <br \/>6. Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, et al. Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial. Gastroenterology. 2015;149:102-109.e6. <br \/>7. Ringel Y, Ringel-Kulka T. The Intestinal Microbiota and Irritable Bowel Syndrome. J Clin Gastroenterol. 2015; 49 Suppl 1:S56-59. <br \/>8. Ohman L, Simr\u00e9n M. Intestinal microbiota and its role in irritable bowel syndrome (IBS). Curr Gastroenterol Rep. 2013;15:323. <br \/>9. Hong SN, Rhee P-L. Unraveling the ties between irritable bowel syndrome and intestinal microbiota. World J Gastroenterol WJG. 2014; 20:2470\u201381. <br \/>10. Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol WJG. 2015; 21:3072\u201384. <br \/>11. Ortiz-Lucas M, Tob\u00edas A, Saz P, Sebasti\u00e1n JJ. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Espanola Enfermedades Dig Organo Of Soc Espanola Patol Dig. 2013; 105:19\u201336. <br \/>12. Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EMM. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut. 2010; 59:325\u201332. <br \/>13. Fern\u00e1ndez-Ba\u00f1ares F, Accarino A, Balboa A, Dom\u00e8nech E, Esteve M, Garcia-Planella E, Guardiola J, Molero X, Rodr\u00edguez-Luna A, Ruiz-Cerulla A, et al. Chronic diarrhoea: Definition, classification and diagnosis. Gastroenterol Hepatol Engl Ed. 2016; 39:535\u201359. <br \/>14. Swidsinski A, Loening\u2013Baucke V, Verstraelen H, Osowska S, Doerffel Y. Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea. Gastroenterology.                                    2008;135:568-579.e2. <br \/>15. Scaldaferri F, Pizzoferrato M, Pecere S, Forte F, Gasbarrini A. Bacterial Flora as a cause or treatment of chronic diarrhea. Gastroenterol Clin North Am. 2012; 41:581\u2013602.  <\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_2 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_2 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_5 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_heading_5 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h4 class=\"et_pb_module_header\">Agenda<\/h4><\/div><\/div>\n\n<div class=\"et_pb_heading_6 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">Knowledge & meetings<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_5 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p style=\"text-align: center;\">Microbiome Center regularly organizes intervisions, webinars and knowledge meetings for doctors and professionals. The sessions are aimed at both healthcare providers who are orienting themselves on microbiome therapy and experienced practitioners who want to deepen their knowledge.<\/p>\n<\/div><\/div>\n\n<div class=\"et_pb_module et_pb_button_module_wrapper et_pb_button_0_wrapper preset--module--divi-button--default_wrapper\"><a class=\"et_pb_button_0 et_pb_button et_pb_bg_layout_dark et_pb_module et_flex_module button_outline preset--module--divi-button--default\" href=\"https:\/\/microbiome-center.nl\/en\/agenda\/\">View the agenda<\/a><\/div>\n<\/div>\n<\/div>\n<\/div><div class=\"et_pb_section_3 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_3 et_pb_row et_flex_row\"><div class=\"et_pb_column_6 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"featured_media":0,"template":"","doelgroep":[106],"class_list":["post-225762","aandoeningen","type-aandoeningen","status-publish","hentry","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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