{"id":225736,"date":"2026-06-26T16:56:29","date_gmt":"2026-06-26T14:56:29","guid":{"rendered":"https:\/\/microbiome-center.nl\/aandoeningen\/cardiovascular-disease\/"},"modified":"2026-06-30T21:52:54","modified_gmt":"2026-06-30T19:52:54","slug":"cardiovascular-disease","status":"publish","type":"aandoeningen","link":"https:\/\/microbiome-center.nl\/en\/aandoeningen\/cardiovascular-disease\/","title":{"rendered":"Cardiovascular disease"},"content":{"rendered":"<style id=\"divi-off-canvas-hide-on-load\">\n[data-interaction-target=\"zwocqpy6qf\"] { display: none !important; }\n<\/style>\n<div class=\"et_pb_section_0 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_0 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_heading_0 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h1 class=\"et_pb_module_header\">Cardiovascular disease<\/h1><\/div><\/div>\n\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p><span data-metadata=\"<!--(figmeta)eyJmaWxlS2V5IjoiN2RYaVBJUWFIeFVVYUdZVllKZTdpNSIsInBhc3RlSUQiOjY3NjY2NTU1MSwiZGF0YVR5cGUiOiJzY2VuZSIsImVudmlyb25tZW50Ijoid3d3LmZpZ21hLmNvbSIsInNlbGVjdGVkTm9kZURhdGEiOiIzNTA3OjQzNjF8MzF8MCJ9Cg==(\/figmeta)-->\" style=\"caret-color: #000000; color: #000000;\"><\/span>Impression of the publications on the relevance of the microbiome<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_1 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_1 et_pb_row et_grid_row\">\n<div class=\"et_pb_column_1 et_pb_column et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>Because most cardiovascular diseases are chronic in nature, there is a growing recognition that this is very closely related to our lifestyle and metabolism. It is therefore often referred to as cardiometabolic diseases. We have explored the coherence for you.  <\/p>\n<p>It may not be obvious to everyone to put cardiovascular disease under the heading metabolic diseases. The reason for this classification is that the risk of cardiovascular disease and the associated risk factors play an important role in metabolic syndrome and is therefore referred to as cardiometabolic diseases (1). There are several factors related to cardiovascular disease, including high blood pressure, a disturbed lipid profile in the blood, atherosclerosis, and systemic inflammation, and there are several indications that suggest a relationship with the microbiome. For example, patients with inflammatory bowel disease have a greater risk of cardiovascular events, despite the fact that they are less likely to have 'classic' risk factors for cardiovascular disease, which indicates a link between gut and heart (2). It is also known that inflammatory reactions are involved in atherosclerosis and that the microbiome influences this (3,4), and that in patients with established atherosclerosis, the composition of the microbiome was more pro-inflammatory compared to healthy subjects (3). Such inflammatory reactions are attributed to bacterial substances that unintentionally enter the blood, which can be the result of increased permeability of the intestinal wall (the so-called 'leaky gut'). In this light, it is striking that in a study more bacterial and viral DNA was found in the blood of patients with various cardiovascular diseases than in healthy control subjects (5). In patients with high blood pressure, the composition and diversity of the microbiome also appears to differ from healthy individuals (6). Moreover, a 'faecal transplant' from those patients to laboratory animals results in a much higher blood pressure in the laboratory animals than a 'faecal transplant' from healthy individuals (6). In studies with probiotic supplementation, an improved lipid profile and reduced blood pressure are found in patients (1,4,7). Finally, in addition to the gut microbiome, the oral microbiome is also an interesting factor in cardiovascular disease. For example, there is a known correlation between periodontal disease and cardiovascular disease, and several studies show that probiotics can positively affect the oral microbiome and, for example, dental plaque, which may help lower the risk of cardiovascular disease (7).           <\/p>\n<\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_2 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_heading_1 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">References<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_2 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>1. Mazidi M, Rezaie P, Kengne AP, Mobarhan MG, Ferns GA. Gut microbiome and metabolic syndrome. Diabetes Metab Syndr. 2016; 10:S150-157.     <\/p>\n<p>2. Singh V, Yeoh BS, Vijay-Kumar M. Gut Microbiome as a novel cardiovascular therapeutic target. Curr Opin Pharmacol. 2016; 27:8\u201312.    <\/p>\n<p>3. Yamashita T, Kasahara K, Emoto T, Matsumoto T, Mizoguchi T, Kitano N, Sasaki N, Hirata K. Intestinal immunity and gut microbiota as therapeutic targets for preventing atherosclerotic cardiovascular diseases. Circ J. 2015; 79:1882\u201390.   <\/p>\n<p>4. Lau K, Srivatsav V, Rizwan A, Nashed A, Liu R, Shen R, Akhtar M. Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases. Nutrients [Internet]. 2017 [cited 2018 Feb 27];9. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5579652\/   <\/p>\n<p>5. Dinakaran V, Rathinavel A, Pushpanathan M, Sivakumar R, Gunasekaran P, Rajendhran J. Elevated Levels of Circulating DNA in Cardiovascular Disease Patients: Metagenomic Profiling of Microbiome in the Circulation. PLoS ONE [Internet]. 2014 [cited 2018 Mar 25];9. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4136842\/   <\/p>\n<p>6. Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome [Internet]. 2017 [cited 2018 Mar 25];5. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5286796\/    <\/p>\n<p>7. Ettinger G, MacDonald K, Reid G, Burton JP. The influence of the human microbiome and probiotics on cardiovascular health. Gut Microbes. 2014; 5:719\u201328.   <\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_2 et_pb_section et_section_regular et_flex_section preset--module--divi-section--default\">\n<div class=\"et_pb_row_2 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_3 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_heading_2 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h4 class=\"et_pb_module_header\">Agenda<\/h4><\/div><\/div>\n\n<div class=\"et_pb_heading_3 et_pb_heading et_pb_module et_flex_module\"><div class=\"et_pb_heading_container\"><h2 class=\"et_pb_module_header\">Knowledge & meetings<\/h2><\/div><\/div>\n\n<div class=\"et_pb_text_3 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p style=\"text-align: center;\">Microbiome Center regularly organizes intervisions, webinars and knowledge meetings for doctors and professionals. The sessions are aimed at both healthcare providers who are orienting themselves on microbiome therapy and experienced practitioners who want to deepen their knowledge.<\/p>\n<\/div><\/div>\n\n<div class=\"et_pb_module et_pb_button_module_wrapper et_pb_button_0_wrapper preset--module--divi-button--default_wrapper\"><a class=\"et_pb_button_0 et_pb_button et_pb_bg_layout_dark et_pb_module et_flex_module button_outline preset--module--divi-button--default\" href=\"https:\/\/microbiome-center.nl\/en\/agenda\/\">View the agenda<\/a><\/div>\n<\/div>\n<\/div>\n<\/div><div class=\"et_pb_section_3 et_pb_section et_pb_section--fixed et_section_regular et_flex_section et-interaction-target-zwocqpy6qf preset--module--divi-section--default\" data-interaction-trigger=\"7hv7hq8l9z\" data-interaction-target=\"zwocqpy6qf\" id=\"video_canvas\"><div class=\"et_pb_row_3 et_pb_row et_flex_row\"><div class=\"et_pb_column_4 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\"><div class=\"et_pb_icon_0 et_pb_icon et_pb_module et_flex_module video_close\"><span class=\"et_pb_icon_wrap\"><span class=\"et-pb-icon\">\uf057<\/span><\/span><\/div><div class=\"et_pb_code_0 et_pb_code et_pb_module\" id=\"microbiome_center_video_iframe\"><\/div><\/div><\/div><\/div>","protected":false},"featured_media":0,"template":"","doelgroep":[106],"class_list":["post-225736","aandoeningen","type-aandoeningen","status-publish","hentry","doelgroep-practitioner"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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